Manufacture of hydrocinchona alkaloids.



- weight.

' UNITED STATES PATENT OFFICE.

HEINRICH THRON, OF FRANKFORTDN THEJJAIN, GERMANY. ASSIGNOR T VERY-JILL IG'IE CHININFAIBRIKEN ZIMMER & 00.. G. M. B. H., 0F ERANKFORT-O'N-THE-MAIN,

Patented Apr. '18, 1911.

GERMANY.

MANUFACTURE or HYDROCINCHONA ALKALoIns.

989,664. Specification of Letters 1 mm.

No Drawing.

Application filed January 13,1911. Serial Ito. 602,515.

To all whom it may concern:

Be it knownthat I, HEINRICH Timon, a subject of the-German Emperor, and resident of Frankforton-the-Main, Germany, haveinvented certain new and useful Improvements in the Manufacture of Hydro cinchona Alkaloids, of which the following is a specification.

In the cinchona, or Peruvian bark. there 1 1 V occur, with too cmchona' fllKRlOldS, smallerquantities of so-calleal h sriro-cinchona-a-lkaloids which differ from the first-named alkaloids in that they contain. two moreatoms of hydrogen. Th preparationof the hydroalkaloids has hitherto only been accomplished by very tronhlesome separation methods, and a synthetic method of manufacture has hitherto been unknown. [I have found that these hydro-einchona5alkaloids can be obtained in a simple manner if the cinchona alkaloids be 'treatedwith hydrogenvin; the presence of a colloidal solution of a metal of the latinum group. t 5

'T e following example illustrates themanner which this invention maybe carried out, but the invention is not limited to thisv precise example. The "parts are by A solution of 2 parts of palladium dichlorid and 2 parts of'gum. arabic in 100 parts of water is treated withhydrogen, until the liquor assumes a deep-black color. Then a solution of 50 parts of quinin hydro chlorid in ,500 parts of Water acidified With parts ofv 10 per cent. hydrochloric acid is .added and' the liquid further agitated with loids by treating a cinchona alkaloid with hydrogen in the presence of a colloidal solution of a metal of the platinum group.

In testimony whereof I have signed my name to this specificationin the presence of two subscribing witnesses.

HEINRICH THRON.

Witnesses JEAN GRUND, Gmmo. 

